Hi Simon,
Some choices will be down to you (flat vs drop bars for example).
I can only pass on my choices and why... so here goes. Bought my first dedicated road bike earlier this year, basically a sportive-spec bike, very light, skinny tyres, carbon fork. Great, fast, bike but not one for wet conditions and no lugs for racks or mudguards. Was going through components at a fair rate (tyres in particular) as I ride 200+ miles a week.
Decided to look for a bike (I wanted drop bars to give alternative riding positions on long rides) that would be robust, capable of doing lots of miles in all weathers and had lugs for racks and mudguards. Eventually discovered cyclocross bikes, and found one that fitted the bill. The one I bought is described in the link below, and was available from my excellent local bike shop at a very good price. It's about 15% lower (easier) geared than my sportive-spec bike, making hills a doddle, relatively. It works well off road too, on tracks and paths (not serious mtb trails obviously).
http://www2.merida-bikes.com/en_GB/Bikes.Detail.180I replaced the rather flimsy cyclocross tyres and tubes with Scwalbe inners and these brilliant tyres (32c) which are very grippy, good in the wet and don't seem to wear. Also they seem to be bulletproof (no sign of punctures or damage in 2.2k miles):
http://www.wiggle.co.uk/p/cycle/7/Vitto ... 360035184/I've ridden 2200 miles in 15 weeks on the bike. Only item that seems to wear is the chain, Shimano HG53, which stretches to 0.75% (when I replace chains) in about 1200 miles. They only cost £10 (ish) and are easy to replace. I'll probably need to replace the front brake pads soon too.
HTH.
CC